TRASTORNOS DE ANSIEDAD

TRASTORNOS DE ANSIEDAD

 

EMOCION

 

MEMORIA EMOCIONAL

 

ANSIEDAD

 

ANSIEDAD GENERALIZADA

La característica esencial del trastorno de ansiedad generalizada es la ansiedad y la preocupación excesivas (expectación aprensiva) que se observan durante un período superior a 6 meses que se centran en una amplia gama de acontecimientos y situaciones (Criterio A). El individuo tiene dificultades para controlar este estado de constante preocupación (Criterio B).

La ansiedad y la preocupación se acompañan de al menos otros tres síntomas de los siguientes: inquietud, fatiga precoz, dificultades para concentrarse, irritabilidad, tensión muscular y trastornos del sueño (en los niños basta con la presencia de uno de estos síntomas adicionales) (Criterio C).

Las situaciones que originan ansiedad y preocupación no se limitan a las que son propias de otros trastornos del Eje I, como el temor a sufrir una crisis de angustia (trastorno de angustia), el miedo a quedar mal en público (fobia social), a contraer una enfermedad (trastorno obsesivo-compulsivo), a estar alejado de casa o de las personas queridas (trastorno por ansiedad de separación), a engordar (anorexia nerviosa), a tener múltiples síntomas físicos (trastorno de somatización) o a padecer una grave enfermedad (hipocondría) y la ansiedad y la preocupación no aparecen únicamente en el transcurso de un trastorno por estrés postraumático (Criterio D).

Aunque los individuos con trastorno de ansiedad generalizada no siempre reconocen que sus preocupaciones resultan excesivas, manifiestan una evidente dificultad para controlarlas y les provocan malestar subjetivo o deterioro so-

MIEDO

FOBIA

TEMOR

 

 

 

 

TRASTORNO POR ESTRES POSTRAUMATICO

 La característica esencial del trastorno por estrés postraumático es la aparición de síntomas característicos que sigue a la exposición a un acontecimiento estresante y extremadamente traumático, y donde el individuo se ve envuelto en hechos que representan un peligro real para su vida o cualquier otra amenaza para su integridad física; el individuo es testimonio de un acontecimiento donde se producen muertes, heridos, o existe una amenaza para la vida de otras personas; o bien 

el individuo conoce a través de un familiar o cualquier otra persona cercana acontecimientos que implican muertes inesperadas o violentas, daño serio o peligro de muerte o heridas graves (Criterio A1).

 

 

 

 

MODELOS ANIMALES PARA EVALUAR ANSIEDAD

EXPLORACION

LABERINTO EN CRUZ ELEVADO

FENOMENO ONE TRIAL TOLERANCE

Fenómeno

(del griego: φαινόμενoν: «apariencia», en plural:   phenomena φαινόμενα) es el aspecto que las cosas ofrecen ante nuestros sentidos; el primer contacto que tenemos con las cosas, lo que entendemos como experiencia. La misma palabra hace pensar que detrás del fenómeno ocurre algo más, que no es perceptible, a lo que el filósofo Emmanuel Kant llamó noúmeno. fenomeno no es mas que fenomeno y ya – no hay mas vuelta al asunto.
Animal defense strategies and anxiety disorders

Rosana Shuhama, cristina m. del-ben, sônia r. loureiro ,frederico g. graeff Anais da Academia Brasileira de Ciências (2007)

Comportamientos defensa:

  1. Amenaza potencial
  2. Amenaza distal
  3. Amenaza proximal

 PERSPECTIVA EVOLUTIVA

 

n      Los procesos que  defiende la selección natural  explica la conservación de las especies

n      Características físicas de los organismos vivos son seleccionados para mantenerse a lo largo de generaciones

n      La perspectiva evolutiva se ha introducido en Psicología

 Nivel de defensa

 

·        Evaluacion riesgo

 

·        Inmobilidad

 

·        Huida

 

·        Amenaza defensiva/ataque defensivo

 

·        Sumision

 defensa

NEUROANATOMIA

caracol

GABA(A)

GABAA_powerponit

NATGEO

ref.OTT LCE

OTT 

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BERTOGLIO LJ, CAROBREZ AP (2000) Previous maze experience required to increase open arms avoidance in rats submitted to the elevated plus-maze model of anxiety. Behav Brain Res 108:197–203.pdf

 

 

  FERNANDES C., FILE SE, 1996. The influence of open arm ledges and maze experience in the elevated plus-maze. Pharmacol.Biochem.Behav. 54, 31-40. .pdf

FILE SE, 1990. One trial tolerance to the anxiolytic effect of chlordiazepoxide in the plus maze. Psychopharmacology 100, 281-282..pdf

FILE S., MABBUT P., HITCHCOTT P., 1990. Characterization of the fenomenon of «one-trial tolerante»  to the anxiolytic effect of chlordiazepoxide in the elevated plus maze. Psychopharmacology 102, 98-101.File SE, Mabbutt PS, Hitchcott P (1990): pdf

 FILE SE, ZANGROSSI H, VIANA M, GRAEFF FG (1993): Trial 2 in the elevated plus-maze: A different form of fear? Psychopharmacology 111:494.pdf

 FILE S., ZANGROSSI H., 1993. «one trial tolerance» to the anxiolytic actions of  benzodiazepines in the elevated plus maze, or the development of a phobic state? Psychopharmacology 110, 240-244. pdf

GONZALES LE, FILE SE.1997. A five minute experience in the elevated plus-maze alters the state of the benzodiazepine receptor in the dorsal raphe nucleus. J Neurosci;17:1505– 11.pdf

  

HOLMES A., RODGERS R., 1999. Influence of spatial and temporal manipulations on the anxiolytic efficacy of chlordiazepoxide in mice previously exposed to the elevated plus-maze. Neuroscience Biobehavioral Reviews 23, 971-980..pdf 

HOLMES A, ILES JP, MAYELL SJ AND RODGERS RJ (2001) Prior test experience compromises the anxiolytic efficacy of chlordiazepoxide in the mouse light/dark exploration test. Behavioral Brain Research 122: 159-167.pdf 

 

 

RODGERS, N.J.T. JOHNSON, J.C. COLE, C.V. DEWAR, G.R. KIDD, P.H. KIMPSON,(1996).Plus-Maze Retest Profile in Mice: Importance of Initial Stages of Trial 1 and Response to Post-Trial Cholinergic Receptor Blockade, Pharmacology Biochemistry and Behavior 54 (1) pp. 41-50..pdf

 

 

 

 

 

Kalueff, AV   Zimbardo, PG(2007) Behavioral neuroscience, exploration, and K.C.Montgomery’s legacy. Brain Behavioural Review 328-331.pdf 

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file_1996.pdf

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L.J. Bertoglio, A.P. Carobrez, Prior maze experience required to alter midazolam effects in rats submitted to the elevated plus-maze, Pharmacology Biochemistry and Behavior 72 (1-2) (2002) pp. 449-455..pdf

  EPM

Pellow S, Chopin P, File SE, Briley M (1985): Validation of open- closed-arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Meth 14:149167

Pellow S & File SE (1986). Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacology, Biochemistry, and Behavior, 24: 525-529.

Dawson Gr,Tricklebank Md: Use of the elevated plus maze in the search for novel anxiolytic agents. 1995.Trends. Pharmacol Sci 16: 33-36. .pdf

S.E. File and P. Seth, A review of 25 years of the social interaction test, European Journal of Pharmacology 463 (2003), pp. 35–53.pdf

R. Lister, The use of a plus-maze to measure anxiety in the mouse, Psychop harmacology, 92, 180 (1987).pdf

Carobrez, A. P. and Bertoglio, L. J. (2005) Ethological and temporal analyses of anxiety-like behavior: The elevated plus-maze model 20 years on. Neurosci Biobehav Rev 29, 1193-1205..pdf

Hogg S (1996) A review of the validity and variability of the. elevated plus-maze animal model of anxiety. Pharmacol. Biochem Behav 54:21–30 .pdf

AMIGDALA

Paré D (2003) Role of the basolateral amygdala in memory consolidation. Prog Neurobiol, 70: 409-420.pdf

file_se_et_al_1999.pdf

file_se_et_al_1998.pdf

barat_m_2006.pdf

GABA_RECEPTOR

 Smith G B Olsen R W 1995 Functional domains of GABA A receptors  Trends Pharmacol. Sci. 16 162 168.pdf

 Wafford, KA; 2005 GABAA receptor subtypes: any clues to the mechanism of Benzodiazepine dependence? Current Opinion in Pharmacology, 5:47–52.pdf 

Whiting, PJ; 2006 GABA-A receptors: aviable target for novel anxiolytics?  Current Opinion in Pharmacology, 6:24–29.pdf

Rudolph, U Crestani, F   and Möhler, H 2001 GABAA receptor subtypes: dissecting their pharmacological functions TRENDS in Pharmacological Sciences Vol.22 No.4 .pdf

Martin, I L and Dunn, S MJ 2002 GABA RECEPTORS Tocris Reviews No.20.pdf

 WESTERN BLOT_GABA

 

francisco-araujo.pdf 

 e-r-korpi.pdf 

 c-pesold-h-j-caruncho.pdf

 k-fuchs-d-adamiker.pdf

 s-chen_1999.pdf

 kathleen-quirk_1995.pdf

k-fuchs-d-adamiker.pdf 

vale%c2%b4rie-campagna-slater.pdf

martin-davies1.pdf  

g-eoffrey-b-smith-and-richard-w-olsen.pdf 

 TRENDS GABA_A

Bormann, J. (2000) The `ABC’ of GABA receptors. Trends Pharmacol. Sci., 21,. 16±19 .pdf

Reynolds DS, McKernan RM, Dawson GR (2001) Anxiolytic-like action of diazepam: which GABAA receptor subtype is involved? Trends Pharmacol Sci 22: 402-403.pdf

Crestani, F.M.H. & Rudolph, U. (2001) Anxiolytic-like action of diazepam: mediated by GABAA receptors containing the α2-subunit. Trends Pharmacol Sci. 22,  403-403(1).pdf

Rudolph U., Crestani F., Möhler H. GABA(A) (2001)  Receptor subtypes: dissecting their pharmacological functions. Trends Pharmacol. Sci. 22 188-194 (2001).pdf

Costa E, Guidotti A. (1996) Benzodiazepines on trial: a research strategy for their rehabilitation. TIPS 17:192-200.pdf 

McKernan RM, Whiting PJ (1996): Which GABAA-receptor subtypes really occur in the brain? Trends Neurosci 19:139-143.pdf

Sieghart W. (2000) Unraveling the function of GABAA receptor subtypes. Trends Pharmacol. Sci. ;21:411–413.pdf  

 INMUNOHISTOQUIMICA

benzodiazepine_mediated_regulation_of_a1__a2__b1_3_and_g2_gabaa.pdf

gabaa_receptor_subunits_in_the_rat_hippocampus.pdf

mmunohistochemistry_as_a_tool_for_topographical_semi_quantification.pdf

modifications_of_y_aminobutyric_acida_receptor_subunit.pdf

temporal_and_regional_regulation_of_a1__b2_and_b3_.pdf

  POWER POINT

 

 Benzodiazepinas.pdf

sk_gaba_receptors_07.pdf 

gaba.ppt

psicofarmacologia-de-la-ansiedad.pdf

ANIMACIONES

http://thebrain.mcgill.ca/flash/i/i_03/i_03_m/i_03_m_par/i_03_m_par_benzodiazepines.html#drogues

INMUNOBLOTING 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

BOTELHO S., CONDE CA., 2003. Modelos animales de estrés post traumático. Salud UIS. 35 97-107

 

 

 

CALZAVARA M., PATTI C., LOPEZ G., ABÝ´LIO V., SILVA R., FRUSSA-FILHO R., 2005. Role of learning of open arm avoidance in the phenomenon of one trial toleranceto the anxiolytic effect of chlordiazepoxide in mice. Life Sciences 76, 2235-2246.

 

 

BERTOGLIO L., CAROBREZ, 2002. Prior maze experience required to alter midazolam effects in rats submitted to the elevated plus- maze 91. Pharmacology Biochemistry and Behavior 72, 449-455.pdf